Methylation Regulates Hepatitis B Viral Protein Expression
نویسندگان
چکیده
منابع مشابه
Methylation regulates hepatitis B viral protein expression.
BACKGROUND Hepatitis B virus (HBV) DNA has been shown to contain CpG islands that are methylated in human tissue, which suggests a role for methylation in regulating viral protein production. However, data are lacking about whether methylation regulates viral gene expression. METHODS To investigate the hypothesis that methylation of viral DNA regulates viral gene expression, unmethylated, par...
متن کاملViral hepatitis, type B.
INTRODUCTION Hepatitis B virus (HBV) is a DNA virus which is highly host and organ specific; to date it has only been found to infect hepatocytes of man and of a few nonhuman primate species. Despite the continuing failure of virologists to find an in vitro system for propagating HBV, it has been possible to gain a great deal of information about the agent and about viral hepatitis, type B, as ...
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Viral hepatitis includes five distinct disease entities, which are caused by at least five different viruses. Hepatitis A and hepatitis B (infectious and serum hepatitis, respectively) are considered separate diseases and both can be diagnosed by a specific serologic test. Hepatitis C and E comprise a third category, each a distinct type, with Hepatitis C parenterally transmitted, and hepatitis...
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More than 400 million people worldwide are chronically infected by the hepatitis B virus. The virus is responsible for more than 300000 cases of liver cancer every year and for similar numbers of gastrointestinal haemorrhage and ascites. Major breakthroughs have been achieved in diagnosis and treatment of this virus. Hepatitis B vaccine reduces incidence of liver cancer. As with hepatitis C, ad...
متن کاملO-11: N-a-acetyltransferase 10 Protein Regulates DNA Methylation and Embryonic Development
Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2009
ISSN: 0022-1899,1537-6613
DOI: 10.1086/597614